Senior Research Associate
Research Member of Common Room
Sir William Dunn School of Pathology
My research is interested in discovering genes and developmental mechanisms that lead to birth defects (congenital malformations). While in the lab of Professor Mustafa Khokha (Yale University) we used a novel gene discovery approach in congenital malformation patients followed by developmental discovery through a variety of approaches.
My work has thus far discovered a novel role for chromatin remodelling (H2B ubiquitylation) in cardiovascular development through modulating cilia motility in collaboration with Harvard University, Colombia University and Icahn School of Medicine Mount Sinai. In addition I also discovered a novel gene essential for mitochondrial biogenesis and metabolism.
I also have an interest in maternal-fetal health. My research has focused on vascular remodelling during pregnancy with emphasis on the role of immune cells in remodelling the maternal spiral arteries during the first trimester of pregnancy to become wide bore channels that allow increased blood flow to the developing embryos. Disorders of this process can lead to pre-eclampsia and fetal growth restriction.